Patterns of pathological tau deposition reflect the dynamics of cortical brain activity.

26 , 34 , 49 Our correlation analyses suggested that reduced gBOLD-CSF coupling (less negative) was associated with higher-order tau across the whole cohort and Aβ+ individuals (both p < 0.026, multiple linear regression), while the coupling-tau link was marginally significant in impaired Aβ+ participants ( p = 0.068; Figure 1E ), reflected by a significant interaction ( p = 0.020) between amyloid and tau on gBOLD-CSF coupling.

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