Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder.

Our stratified analysis showed that patients with the highest genetic loading for acetylcholine, GABA, and calcium channel pathway variants (in the 10th decile) had a good lithium treatment response compared with patients with the lowest genetic loading (in the 1st decile), with an increasing trend of lithium treatment responsiveness across the 1st decile to the 10th decile.

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With a decreasing trend across deciles, BD patients with the highest genetic loadings for mitochondria variants (10th decile) had 52% lower odds of responding to lithium than patients with the lowest genetic loadings (1st decile); aOR = 0.52 (95% CI, 0.33 to 0.80) ( Figure 2 ).

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