Neuronal endolysosomal alterations induced by Apolipoprotein E4 emerge over time in primary neurons.

At 25 to 26 DIV, ApoE4 cultures continued to show a notable trend toward reduced levels of Complex I, but at this time point, so did ApoE KO cultures, and ApoE3 cultures showed the highest levels of Complex I, although these did not reach significance.

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When evaluating how the cholesterol levels, measured by Filipin intensity, changed after cholesterol supplementation, we could detect a nonsignificant trend for ApoE3 neurons showing an increase in their membrane cholesterol levels, with the most in neuronal cell bodies, while there was no appreciable change in dendrites ( Fig. 6 , G and H ).

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