Barely Significant
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Prevalence of Vitamin B12 Deficiency in Type 2 Diabetic Patients on Long-Term Metformin Therapy.

Cureus · 2025 · PMC12358324 · PMID 40831865

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highly significantno p-value reported
The chi-square values (434.286 for duration and 80.00 for dose) and p-values (<0.001) indicate a highly significant association between both variables and vitamin B12 deficiency, suggesting that longer duration and higher doses of metformin are strongly linked with increased risk of vitamin B12 deficiency (Table 3 and Figure 1 ).

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