Effects of the δ-aminolevulinic acid dehydratase polymorphism rs1800435 on blood lead levels: a new systematic review and meta-analysis.

Sci Rep · 2025 · PMC12358600 · PMID 40820147

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hedged sentences

0.0610

closest p · 1.2× alpha

0.0610

boldest claim

The sentences

marginally significantp = 0.061so close (0.05 < p ≤ 0.1)

For non-lead-exposed respondents, blood lead levels in male ALAD2 allele carriers demonstrated a marginally significant decrease compared with those in male ALAD1 homozygotes ( p = 0.061).

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marginal significanceno p-value reported

However, in both adults and children, BLLs in male ALAD2 allele carriers were marginally significantly lower than those in male ALAD1 homozygotes (WMD = − 0.349, 95% CI − 0.016 ~ 0.713, p = 0.061, marginal significance, I 2 = 0%) (Fig. 5 ).

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borderline significantno p-value reported

The homogeneous and borderline significant results in male populations warrant further sex-specific investigations to clarify potential biological mechanisms.

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