borderline significantp = 0.070
In part, this was also seen using ISUP grading and TNM stage 8th edition, showing a statistically significant association between methylated LAD1 and NEURL , and ISUP grading ( p = 0.011 and 0.004, respectively) and a borderline significant association between methylated LAD1 and TNM stage 8th edition ( p = 0.070).