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Zinc oxide nanoparticles disrupt peroxisome-endoplasmic reticulum contacts and increase very-long-chain fatty acid content.

J Biol Chem · 2025 · PMC12359231 · PMID 40680838

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extremely significantno p-value reported
The results showed that the expression of genes encoding enzymes related to acetylation and deacetylation modifications were drastically altered, with extremely significant changes in sirt1 , ep300a , and hdac7 ( Fig. 4 A ), indicating that acetylation or deacetylation modifications may play an important role in the effects of ZnO NPs.

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