High-dose multi-strain Bacillus probiotics enhance treatment and reduce antibiotic usage in children with persistent diarrhea through immune and microbiota modulation.

Sci Rep · 2025 · PMC12361499 · PMID 40826150

Europe PMC DOI

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0.0916

closest p · 1.8× alpha

0.0916

boldest claim

The sentences

a decreasing trendp = 0.0916so close (0.05 < p ≤ 0.1)

We observed that over the course of 5 days, LiveSpo DIA30 treatment led to a significant decrease in IL-17 and IL-23 (by 26.62% and 25.13%, with p values of 0.0178 and 0.0256, respectively), a 19.09% ( p = 0.038) reduction in TNF-α signaling and a decreasing trend in IL-6 (8.54%; p = 0.0916) (Fig. 3 A-D).

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