Non-synaptic interictal epileptiform discharges propagating from CA3 to CA1 induce synaptic depression in the hippocampus.

However, in the final 6 min of the recording, the slopes revealed a highly significant difference between the control and 4‐AP groups ( n = 5 in the control group and n = 10 in the 4‐AP group, p < 0.001).

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The slopes of pEPSP for the experimental group with a cut t indicate a decreasing trend similar to the results obtained without the cut (Figure 4E ).

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