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The chronODE framework for modelling multi-omic time series with ordinary differential equations and machine learning.

Nat Commun · 2025 · PMC12365117 · PMID 40830112

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a decreasing trendno p-value reported
Moreover, although gene activation and repression were largely conserved, with nearly 100% of the genes showing either always an increasing or always a decreasing trend across the three brain regions, their kinetic patterns varied significantly.

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