DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation.

GSEA of MicroRNAs (miRNAs) revealed that the differentially expressed gene sets from both DDR1i and RUNXi treatment groups overlapped with genes regulated by miR-93, significantly with miR-93-5p ( p = 9.27e−3 for DDR1i; p = 9.86e−6 for RUNXi), and trending toward significance for miR-93-3p ( p = 0.0566 for DDR1i; p = 0.086 for RUNXi) ( Figures S5 B and S5C). miR-93 expression is known to be repressed by RUNX1 and other members of the RUNX TF family and has been implicated in migration and proliferation of normal and cancerous cells ( Bao et al., 2020 ).

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Further analysis of this database revealed a highly significant tendency for the co-occurrence of mutations in DDR1 and RUNX1 as well as in DDR1 and CBFβ , while RUNX1 and CBFβ mutations tend to be mutually exclusive, as expected ( Figure 6 B).

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