Association of IL-10, IL-6, and TNF-α polymorphisms with acute coronary syndrome risk: a systematic review, meta-analysis, and trial sequential analysis.

BMC Med Genomics · 2025 · PMC12374326 · PMID 40846944

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an increasing trendno p-value reported

However, TNF-α –308G > A showed significant positive associations with publication year across all genetic models, indicating an increasing trend over time, but no significant association with sample size.

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