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The transcription factor FOXA1 upregulates PYCR1-mediated autophagy to suppress antitumor immunity in lung adenocarcinoma.

Cancer Immunol Immunother · 2025 · PMC12374928 · PMID 40848149

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The relationship between PYCR1 expression and prognosis was then assessed by K–M curves based on the sample information from the TCGA database, which identified a positive trend between the upregulation of PYCR1 and poorer overall survival in LUAD patients (Fig. 1 b).

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