Down syndrome burden in China and globally: a comparative analysis of 1990-2021 trends and future projections based on GBD 2021 database.

Front Public Health · 2025 · PMC12375605 · PMID 40860557

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an increasing trendno p-value reported

In high-SDI countries, there is an increasing trend of women delaying childbearing until they are ≥35 years old ( 41 ), theoretically elevating DS incidence rates due to the exponential increase in DS risk associated with maternal age ( 42 , 43 ).

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