Activated Growth Factor (AGF) as a Superior Biological Therapy for Osteoarthritis: Comparative Efficacy in Modulating Cartilage Degeneration and Inflammation in vivo.

Compared to the Normal Control (NC) group, which exhibited basal physiological levels of these enzymes (MMP-1: 5.2±0.8 ng/mg protein; MMP-13: 3.9±0.6 ng/mg protein; ADAMTS-4: 2.3±0.4 ng/mg protein), the OA Control group displayed a highly significant (p < 0.001 for all) upregulation of MMP-1 (to 15.8±2.1 ng/mg protein, approximately a 3-fold increase), MMP-13 (to 12.5±1.7 ng/mg protein, approximately a 3.2-fold increase), and ADAMTS-4 (to 9.1±1.2 ng/mg protein, approximately a 3.95-fold increase).

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