Spreading depolarization triggers pro- and anti-inflammatory signalling: a potential link to headache.

Brain · 2025 · PMC12378585 · PMID 39823578

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hedged sentences

0.0005

closest p · 0.0× alpha

0.0600

boldest claim

The sentences

highly significantP = 0.0005actually significant

62-66 Supporting this, genes encoding the C-chain polypeptide of complement subcomponent C1q (a key mediator of microglia-mediated spine pruning) demonstrated a subtle yet highly significant upregulation of 15% ( P = 0.0005, adjusted P = 0.0492) in microglia. 67-69 Discussion We found that the pro-inflammatory stimuli from neurons that drive inflammatory signalling in astrocytes/microglia diminished a few hours after a single CSD.

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a decreasing trendP = 0.06so close (0.05 < p ≤ 0.1)

51 , 52 We observed that the active enzyme ratio in cortical lysates was 11% ± 3.0% at 1 h post-CSD, showing a decreasing trend over 5 h ( P = 0.06; n = 3; Supplementary Fig. 1B ).

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