Characteristics of NRAS-mutated patients with chronic myelomonocytic leukemia in a national (ABCMML) and an international cohort (cBioPortal).

Wien Med Wochenschr · 2025 · PMC12380971 · PMID 40372530

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0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

borderline significancep = 0.06so close (0.05 < p ≤ 0.1)

Thus, looking at these data and findings in our study, it seems that the likelihood that NRAS mutations will become a significant prognostic factor is dependent on the size of the cohort, since in all four cohorts consisting of more than 200 patients, including the ABCMML, NRAS mutations had a significant adverse impact on OS in three of them and borderline significance ( p = 0.06) in one cohort.

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