Fibroblast activation protein expression in the tumor microenvironment is crucial in survival prediction and differentiation of recurrent gliomas: a head-to-head comparison of <sup>68</sup>Ga-FAPI-04 and <sup>18</sup>F-FET in PET/CT imaging.

EJNMMI Radiopharm Chem · 2025 · PMC12381343 · PMID 40856882

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0810

boldest claim

The sentences

marginally non-significantP = 0.053so close (0.05 < p ≤ 0.1)

Univariate logistic regression analysis revealed a marginally non-significant difference in efficacy ( P = 0.053) of the initial pathological diagnosis.

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tended toward significanceP = 0.081so close (0.05 < p ≤ 0.1)

The regression results showed that two parameters were insignificant but tended toward significance: the MTV FAPI :MTV FET ratio ( P = 0.081) and the initial WHO grade ( P = 0.086).

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trend toward significanceno p-value reported

However, the MTV FAPI :MTV FET ratio, an index reflecting the percentage of FAP overexpression from CAFs in the entire tumor microenvironment of the glioma parenchyma, showed a non-significant trend toward significance in distinguishing recurrent glioma from treatment-related changes, including radiation necrosis or pseudoprogression.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Fibroblast activation protein expression in the tumor microenvironment is crucial in survival prediction and differentiation of recurrent gliomas: a head-to-head comparison of &lt;sup&gt;68&lt;/sup&gt;Ga-FAPI-04 and &lt;sup&gt;18&lt;/sup&gt;F-FET in PET/CT imaging.

The sentences

Fibroblast activation protein expression in the tumor microenvironment is crucial in survival prediction and differentiation of recurrent gliomas: a head-to-head comparison of <sup>68</sup>Ga-FAPI-04 and <sup>18</sup>F-FET in PET/CT imaging.