In addition, following the selection of glycemic SNPs (serving as the exposure instrumental variable), and utilizing genetic variants that are strongly associated with the molecular targets of hypoglycemic agents (typically loss-of-function variants or highly significant SNPs) as instrumental variables, we conducted an analysis to assess the presence of a strong genetic linkage disequilibrium (LD) or significant genetic covariance between the selected glycemic SNPs and the “drug target instrumental variable”.
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The association of metabolic syndrome with aortic aneurysm: a two-sample Mendelian randomization study.
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