Chronic antigen stimulation in melanoma induces T cell exhaustion and limits efficacy of T cell bispecific therapies.

Furthermore, a decreasing trend in the Granzyme B effector marker was observed in both tumor antigen-specific and nonspecific CD8 + T cell compartments over the course of tumor progression ( Figure 1d ), potentially explaining tumor escape, despite the presence of OVA-specific CD8 + T infiltration.

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