Effects of paeoniflorin on CUMS-induced metabolic changes Our previous research identified similar metabolic changes in hippocampal and jejunal tissues in the CUMS model, notably significant decreases in l -glutamine, l -tyrosine, 3-phosphoglyceric acid and hydroxylamine, alongside an increasing trend in GABA levels. 11 These common gut–brain differential metabolites are potentially the hub of a broader gut–brain connection.
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Paeoniflorin ameliorates depressive behaviours by modulating microbiota-gut-brain axis functions.
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