A Mendelian randomization study of the associations between depression, anxiety and clinical conditions including thyroid nodules, flatulence, and irregular menstruation.

Although the P -value obtained from the MR-Egger intercept test resides in a marginally significant range, converging lines of evidence, including stable effect estimates from leave-one-out sensitivity analyses and visual inspection of a symmetric funnel plot, collectively suggest that pleiotropic effects are unlikely to substantially confound the study’s inferences.

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