In Vitro Modeling of Diurnal Changes in Bone Metabolism.

Int J Mol Sci · 2025 · PMC12386813 · PMID 40869020

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an increasing trendno p-value reported

While there is no report in the literature on BMAL1 effects on M-CSF or RANKL expression, OPG expression was reported to be directly controlled by BMAL1 in osteoblastic cells [ 36 ], supporting our finding that OPG levels show an increasing trend throughout the day.

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