Formulation-Driven Optimization of PEG-Lipid Content in Lipid Nanoparticles for Enhanced mRNA Delivery In Vitro and In Vivo.

Pharmaceutics · 2025 · PMC12388858 · PMID 40870973

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a decreasing trendno p-value reported

With increasing DMG-PEG content, the zeta potential exhibited a decreasing trend, likely due to enhanced surface shielding by the PEG chains.

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