Safety and Immunogenicity of a 23-Valent Pneumococcal Polysaccharide Vaccine (PPSV23) in Chinese Children, Adults and the Elderly: A Phase 4, Randomized, Double-Blind, Active-Controlled Clinical Trial.

Vaccines (Basel) · 2025 · PMC12389771 · PMID 40872951

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an increasing trendno p-value reported

The highest immune responses were observed in children and adolescents in terms of ≥2-fold increase rates for most serotypes, and the lowest were in the elderly, while GMCs showed an increasing trend with age, suggesting the pre-existing antibody levels and the immune function may influence the immune response.

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