Remodeling adipocytes' lipid metabolism with a polycation loaded enzyme-active framework reverses osteoporotic bone marrow.

The number of mitochondrial cristae in MC3T3-E1 cells in the ADI group was clearly significantly reduced, and even mitochondrial fragmentation occurred, which was slightly rescued in the CZ or CZ@LC groups, whereas the number of mitochondrial cristae (yellow arrow) was rescued in the CZP or CZP@LC groups due to robust inhibition of lipid synthesis (Fig. 8I ).

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