Leukocyte-type 12/15-lipoxygenase is essential for timely inflammation-resolution and effective tissue regeneration following skeletal muscle injury.

Alox15 −/− mice showed a statistical trend ( p = 0.055) toward greater numbers of intramuscular PMNs (GR1 + cells) ( Figure 1 I), as well as more total MФ (CD68 + cells) ( Figure 1 J), and M2-like MФ (CD68 + CD163 + cells) ( Figure 1 K).

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