Barely Significant
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Alterations in ether lipid metabolism in obesity revealed by systems genomics of multi-omics datasets.

PLoS Biol · 2025 · PMC12393746 · PMID 40875616

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hedged sentence
0.0000
closest p · 0.0× alpha
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boldest claim

The sentences

highly significantp-value = 8.07 × 10 −107actually significant
As anticipated, lipid ratios capturing PUFA synthesis, namely PE(P-16:0_18:2)/PE(P-16:0_20:4), PE(P-18:0_18:2)/PE(P-18:0_20:4), PE(P-16:0_18:3)/PE(P-16:0_20:5) and PE(P-18:0_18:3)/PE(P-18:0_20:5), exhibited highly significant associations with FADS1/FADS2/FADS3 loci [575 SNPs; top hit: rs174564 for the PE(P-18:0/18:2)/PE(P-18:0/20:4); imputation r 2 = 0.999; beta = 0.49; p-value = 8.07 × 10 −107 ; p-gain = 2.60 × 10 +83 ].

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