Optogenetic silencing of hippocampal inputs to the retrosplenial cortex causes a prolonged disruption of spatial working memory.

Results Injection of AAV-5-hSyn1-eArch3.0 results in significant expression of a fluorescent tag in RSC hippocampal terminals Besides abundant expression of both eArch and CTRL transgenes in hippocampal CA1, we found highly significant expression in the RSC layers as previously reported ( Figure 1A—figure supplement 1 ; Ferreira-Fernandes et al., 2019 ).

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The effects were rather subtle, rendering some of the results barely significant and possibly too weak to support major conclusions.

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