Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes.

Elife · 2025 · PMC12393883 · PMID 40874922

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a decreasing trendno p-value reported

The knockdown of ID1 and ID2 via shRNA or an ID1 inhibitor resulted in a decreasing trend of ID1 or ID2 expression and a significant increase in p16 and p21 expression ( Figure 3F, I ).

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