Optogenetic light were given at 11–18 trials of looming tests, and the behavioral results revealed that the activation of SuM-DG circuit significantly enhanced alertness levels given the reaction time to the looming stimulation was decreased when blue light was given, while inhibiting the SuM-DG circuit after the alertness stimulation response reached a plateau demonstrated a small trend toward increased reaction time in looming tests (Fig. 3G and H ), suggesting that activating the SuM-DG pathway before reaching the alertness plateau plays a critical role in the alertness phenotype.
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Activation of the supramammillary-dentate gyrus circuit enhances alertness and cognitive function in a rat model of ADHD.
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