highly significantp < 0.001
In terms of OS, a similar highly significant difference could be seen between subgroups ( p < 0.001, mOS:nr for low,nr for low-intermediate, 12.0 months for high-intermediate and 17.3 months for high, Figure 5G ) with the most profound difference seen in patients with a score > 5 vs ≤ 5 ( Figure 5H ).