Dual inhibition of ACE-2 and TMPRSS2: A promising strategy to mitigate SARS-CoV-2 severity in smokers.

Mol Ther Nucleic Acids · 2025 · PMC12397935 · PMID 40896581

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Yet, the most profound effect was achieved when the two treatments were combined; the dual blockade led to a dramatic and highly significant reduction in SARS-CoV-2 infection that was far superior to either monotherapy ( Figure 1 ).

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