A tumor microenvironment-responsive Zr-MOF nanosystem for co-delivering siHIF-1α and triptolide enhances photodynamic therapy in esophageal cancer by amplifying ROS generation and reversing hypoxia.

Mater Today Bio · 2025 · PMC12398845 · PMID 40893379

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an increasing trendno p-value reported

However, the tumor volume of mice in this group showed an increasing trend after 10 days, indicating that the tumor inhibitory effect of TPL/siHIF-1α@Zr-MOF@CM treatment was limited.

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