Patient-Reported Outcomes and Body Composition Changes in Patients With Colorectal Cancer During Chemotherapy: A Longitudinal Study.

Analysis of Trends and Trajectories in Self-Reported Symptoms Patient self-reported symptoms showed an overall general trend of change, with an increasing trend from T1 to T2 (0.67%), and then a gradual decrease from T2 to T3 (−2.79%), resulting in a downward trend from T1 to T3 (−2.03%).

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An analysis of the trends of each body composition variable revealed that all body composition indicators had an increasing trend, except for the patients' skeletal muscle mass and upper limb grip strength, which showed a decreasing trend ( Figure 4 ). 3.4.2.

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Such an overall trend reflects the average change in the subjective experience of chemotherapy among the study population; the adverse reactions caused by chemotherapy gradually worsened from the early stage (within 1 month) to the middle stage (1–3 months) of chemotherapy.

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