Barely Significant
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Global, regional, and national burdens of congenital heart anomalies from 1990 to 2021, and projections to 2050.

Front Pediatr · 2025 · PMC12399661 · PMID 40901529

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an increasing trendno p-value reported
Notably, age-standardized YLDs have shown an increasing trend in non-high SDI regions, indicating a growing burden of disability ( Figures 1E,F ).

also in 63,971 other papers

a decreasing trendno p-value reported
The prevalence rate for children aged 0–4 is notably high in all SDI regions, with a decreasing trend in prevalence as age groups progress from 5 to 9 to 65–69 years.

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.