Barely Significant
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Prognostic utility of the CALLY index in metastatic melanoma: building a nomogram for Patients on Anti-PD-1 therapy.

Clin Transl Oncol · 2025 · PMC12399701 · PMID 40091005

2
hedged sentences
0.0500
closest p · 1.0× alpha
0.0910
boldest claim

The sentences

borderline significantp = 0.050actually significant
Multivariate analysis revealed the M1c stage to be an independent predictive factor in relation to the objective response ( p = 0.046), while a low CALLY index was a borderline significant predictive factor ( p = 0.050).

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a trend towards significancep = 0.091so close (0.05 < p ≤ 0.1)
Indeed, in our baseline comparisons, LDH was significantly higher in the low CALLY group ( p < 0.001), and stage M1c/M1d demonstrated a trend towards significance ( p = 0.091), whereas other variables did not differ.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.