Immune checkpoint inhibitors use in liver transplantation for hepatocellular carcinoma: a global cohort study.

For washout period, a duration >30 days was linked to a lower risk of graft rejection (OR=0.36, 95% CI: 0.18–0.72, P =0.004), consistent across models: Model 1 OR=0.35 (95% CI: 0.17-0.70, P =0.003), Model 2 OR=0.38 (95% CI: 0.18-0.78, P =0.008), Model 3 OR=0.40 (95% CI: 0.18-0.86, P =0.019), Model 4 OR=0.37 (95% CI: 0.17-0.77, P =0.008), and Model 5 OR=0.36 (95% CI: 0.17-0.75, P =0.006); Model 6 showed marginal significance (OR=0.42, 95% CI: 0.16-1.11, P =0.071).

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Nonetheless, the curves suggested a possible trend toward reduced survival in the rejection group at later timepoints, which may reflect limited sample size.

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