highly significantP < 0.05
P -values were calculated, and statistical significance was reported as highly significant with * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001; n.s., not significant.
P -values were calculated, and statistical significance was reported as highly significant with * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001; n.s., not significant.