Low-Intensity pulsed ultrasound enhances paracrine secretion of IGF and VEGF by bmscs, promoting osteogenesis and angiogenesis.

LIPUS-mediated promotion of osteogenic differentiation in BMSCs via paracrine signaling Effects of conditioned media on proliferation and migration of BMSCs According to the cell proliferation curves, there was no significant difference in the proliferation ability between the BMSCs-LIPUS-CM and BMSCs-Ctrl-CM groups, although the BMSCs-LIPUS-CM group showed a slight trend of enhanced proliferation at the early stage ( Fig. 3 A ) .

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