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Variation in risk of opioid therapy and association with mortality following hip or knee arthroplasty: an analysis based on 14 different definitions.

Acta Orthop · 2025 · PMC12404099 · PMID 40891928

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a decreasing trendno p-value reported
Our findings also indicate a decreasing trend in LTOT risk from 2016 to 2019 for all definitions, which has been seen in other studies [ 1 , 22 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.