Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action.

J Exp Med · 2025 · PMC12404154 · PMID 40892070

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highly significantno p-value reported

Surprisingly, when we examined BAL-0028 in mouse macrophages, we noticed a highly significant decrease in its ability to inhibit NLRP3 ( Fig. 3 ).

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