Barely Significant
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Understanding the first prescription: clinical and demographic drivers of strong opioid use in primary care.

Pain Med · 2025 · PMC12405760 · PMID 40306260

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a decreasing trendno p-value reported
1 Despite evidence of a decreasing trend after opioid-restricting guidelines were implemented, considerable opioid-related harm persists, 3 , 4 and in some cases it disproportionately affects disadvantaged populations. 5 Worldwide, 80% of drug-related fatalities were related to opioids in 2019. 6 According to a 2022 global cross-sectional study, Australia has the sixth-highest opioid consumption per capita.

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