A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers.

Additionally, we identified nine novel potential associated signals with borderline significance in the NUAK1 | CKAP4 , ST6GALNAC3 , LOC105379385 , GPRC5A , GTDC1 , FILNC1 , CEP128 , LOC105376235 and COL25A1 loci associated with de increased levels of IgG after third month vaccine ( p =1.58×10 -7 -9.58×10 -7 , Supplementary Table 5 ).

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Interestingly, we also identified 19 novel potentially interesting associations with increased circulating concentrations of IgG at 1-month post-vaccination, which remained borderline significant.

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