Cardioneuroablation for Asystolic Reflex Syncope: How to Identify the Best Candidate and How to Predict Success.

In the PIRECNA registry there was only a nonsignificant trend for better outcome in the group with ablation conducted by an experienced operator [HR 0.52; 95% CI [0.19–1.41]; p=0.19], whereas in the multi-centre study by Aksu et al. there was virtually no difference between procedure-naïve operators and experienced ones. 28 , 62 These results may be explained by the fact that, from a technical point of view, CNA is not a difficult procedure for an operator who is experienced in performing complex ablation procedures, including ablation for AF.

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When combined, the use of ECVS seems to be associated with better outcome (91% versus 82% of patients free from syncope recurrence), but with a p-value of a borderline significance.

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