Adaptive individualized gene pair signatures distinguishing melanoma and predicting response to immune checkpoint blockade.

iScience · 2025 · PMC12410410 · PMID 40917881

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a trend toward significancep = 0.06so close (0.05 < p ≤ 0.1)

The Riaz cohort demonstrated significant differences in OS (Kaplan-Meier log rank test p = 0.004, HR = 3.24, 95% CI: 1.40–7.51) and a trend toward significance in PFS (Kaplan-Meier log rank test p = 0.06, HR = 1.86, 95% CI: 0.97–3.56).

also in 2,207 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.