Pathotype-Specific Expression of Granzyme-Perforin Pathway Genes and Their Association With Clinical Disease Activity in Early Rheumatoid Arthritis and in a Randomized Clinical Trial.

Interestingly in the eRA synovium from PEAC study, the correlations between baseline GZM A and DAS28-ESR were positive and highly significant ( r =0.31, p=0.0048) ( Fig. 3A ), GZM B and DAS28-ESR ( r =0.29, p=0.0077) ( Fig. 3B ), GZM K and DAS28-ESR ( r =0.33, p=0.0031) ( Fig. 3C ), GZM H and DAS28-ESR ( r =0.27, p=0.015) ( Fig. 3D ), GZM M and DAS28-ESR ( r =0.33, p=0.0023) ( Fig. 3E ), PRF-1 and DAS28-ESR ( r =0.39, p=0.00033) ( Fig. 3F ), SRGN , DAS28-ESR ( r =0.31, p=0.054) ( Fig. 3G ) and CD27 ( r =0.30, p=0.007) ( Fig. 3H ).

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