Exploring the protective mechanisms of the yunpi jiedu tongluo qushi decoction on methotrexate-induced reproductive damage in male rats based on Nrf2/HO-1 signaling pathway.

Front Cell Dev Biol · 2025 · PMC12411506 · PMID 40917752

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a decreasing trendP < 0.001actually significant

Following MTX intervention, both the testicular organ coefficient and epididymal organ coefficient in rats showed a decreasing trend, with statistical significance observed in all cases except for the left testicular organ coefficients ( P < 0.001, P < 0.01, P < 0.05, P > 0.05).

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