Nobiletin Modulates Adipocyte-Derived Exosomal miRNA to Improve Liver Lipid Metabolism in Obese Mice.

In contrast, AMPK expression levels in the HFD + ob-ELVs and the HFD + Nob-ELVs groups show a decreasing trend compared to the HFD group, indicating that both ob-ELVs and Nob-ELVs are ineffective in activating AMPK ( Figure C).

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Notably, the SIRT1 expression level in the HFD + Nob-ELVs group exhibited an increasing trend compared to the HFD group, implying that nobiletin may further activate SIRT1 by modulating adipocyte-derived extracellular vesicles ( Figure B).

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