Active chromatin marks and up-regulation of FOXC1 in uterine epithelial cells demarcate the onset of reproductive decline in aging females.

NAR Mol Med · 2025 · PMC12414250 · PMID 40922722

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highly significantno p-value reported

This elevated abundance was more pronounced for H3K27ac compared to H3K4me3, and identified Foxc1 as the most affected locus where the gain in H3K27ac was already highly significant in A1 and clearly preceded that of H3K4me3 (significant from A2 on).

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